September 22, 2022
ASUS Announces ExpertCenter PN53
ExpertCenter PN53, a mini PC that harnesses the power of the latest AMD Ryzen™ 6000 series processor with AMD Radeon™ 600M series graphics

TAIPEI, Taiwan, September 22, 2022 — ASUS today announced ExpertCenter PN53, a mini PC that harnesses the power of the latest AMD Ryzen™ 6000 series processor with AMD Radeon™ 600M series graphics. PN53 can be specified with up to a Ryzen 9 processor and it offers a triple-storage design that can accommodate various storage combinations. Two PCIe® Gen 4 M.2 SSDs and DDR5 memory support ensure fast boot-up and app loading times. In addition, PN53 includes cleverly designed cooling features, AI-powered noise-cancelation technology for improved communication, and can support up to one 8K UHD or four 4K displays.

PN53 offers up to 34% better single-thread performance and up to a 29% boost in multi-thread performance, versus the previous PN51 model. In PCMark10 Essentials group tests, PN53 showed a 10% improvement in web browsing, videoconferencing, and app start-up times. PN53 also performed 10% better than PN51 in the Productivity test group that measures system performance with everyday office applications, including spreadsheets and writing workloads.

  • Ultrafast PCIe 4.0 SSD

  • PCIe 4.0 offers twice the data transfer rate of the prior PCIe 3.0 standard. ExpertCenter PN53 supports one PCIe Gen4 x4 SSD to deliver greater data performance and lower latency.

  • Hyper-fast 2.5 Gbps networking

  • Next-generation 2.5GBase-T (2.5 G) networking technology delivers speeds of up to 2.5 Gbps, allowing PN53 to handle the most data-intensive tasks at work or in the office.

  • Anti-dust self-cleaning system

  • This cleaning system keeps the heatsinks clean and effectively ejects dust and other particles to help prolong the lifespan of PN53. The fan is never overworked, so less noise is generated.

  • Extreme cooling

  • To ensure sustained high-end performance in a compact machine, ASUS designers and engineers fine-tuned every aspect of PN53’s cooling system. The self-cleaning fan module includes flat heat pipes connected to full-sized heatsinks and fan outlets to improve heat dissipation, allowing the CPU to operate at optimum temperatures.

  • Support for four 4K or one 8K UHD display

  • PN53 can support four 4K displays via its two HDMI® ports, DisplayPort™ (USB-C®) and additional configurable port―so it’s perfect for multi-display installations or video walls in stores, restaurants, hotels, or public spaces. Quad-display support is also useful in office settings, making it easy to extend workspaces. In addition, PN53 can support one 8K display.

  • Two-Way AI Noise Cancelation

  • Integrated AI-powered noise-cancelation technology includes both input and output noise cancelation for crystal-clear communication. It’s ideal for use in educational, office or home office/small office (SOHO) settings.

  • Smart Fan Control

  • Exclusive Smart Fan Control technology enables users to tailor fan modes to suit their requirements, all via a user-friendly interface. Quiet mode delivers low-noise performance and Standard mode supports sustained peak performance during data processing.



Windows®11 (64 bit)
Windows®11 Pro (64 bit)
Without OS


AMD Ryzen™ 9 6900HX, (cTDP 35 W)
AMD Ryzen™ 7 6800H, (cTDP 35W)
AMD Ryzen™ 5 6600H (cTDP 35W)




Integrated: AMD Radeon™ Graphics 680M (R9/R7) or 660M (R5)


2 x SO-DIMM, DDR5-4800 MHz (up to 16 GB x 2)


2 x M.2 2280, up to PCIe® Gen4 x4, 256 GB–2 TB SSD
1 x 2.5” 7 mm SATA 6 Gb/s 1 TB HDD, 7200 rpm
*Support NVMe®

Wireless Network

WiFi 6 and Bluetooth® 5 or
WiFi 6E and Bluetooth® 5


2.5 G LAN, 10/100/1000/2500 Mbps


Front I/O

1 x USB 4 Type-C® (supports DisplayPort™ 1.4)
2 x USB 3.2 Gen 1
1 x Audio jack (Line out, mic in, headphone out)

Side I/O

1 x Kensington lock

Rear I/O

1 x USB 4 Type-C® (supports DisplayPort™ 1.4, Power Delivery input*)
3 x USB 3.2 Gen 1
2 x HDMI® 2.1 (Up to 4K @ 60 Hz)
1 x Configurable port
(options: DisplayPort™ 1.4, HDMI® 2.1, COM, VGA)
1 x 2.5 Gb RJ45 LAN
1 x DC-in
1 x Padlock ring
*Supports up to 4 displays simultaneously
*Power supply needed to support Power Delivery & at least 100 W output


TPM 2.0 or TPM module onboard (optional)



120 x 130 x 58 mm


0.9 kg

Power Supply

20 V DC, 19 V DC, 6.0 A / 6.32 A 120 W power adapter (R5 SKU)
20 V DC, 7.5 A 150 W power adapter (R7/R9 SKU)