ASUS ExpertCenter PN53-S1

Ultra-compact mini PC with AMD Ryzen™ 7000U Series Processor and AMD Radeon ™ Graphics, supports Quad displays and 4K resolution, 1x PCIe® Gen3x4 M.2 NVMe™ SSD, 2.5 Gb LAN, WiFi 6E
  • Powered by the latest AMD Ryzen™ 7000U Series Processor with Radeon™ graphics
  • Quad-4K displays support via including configurable port
  • Support 6 USB ports, including two Type C ports, on-board HDMI and configurable port
  • Multi-storage design, support up to up to 1x M.2 PCIe® Gen3x4 SSD and 1x HDD
  • Features Two-Way AI Noise Cancelation to provide crystal-clear online voice communication
  • Onboard 2.5GbE LAN delivering faster Ethernet connectivity
  • Integrated Wi-Fi 6E and Bluetooth for easy cordless connections
  • Configurable Ports support DP1.4/VGA/COM/LAN options
  • 24/7 reliability — Extensively tested to ensure long-term dependability
ASUS ExpertCenter PN53-S1
Black PN53-S1

Ultra-compact Mini PC provides flexible, comprehensive solutions

ASUS ExpertCenter PN53-S1 is no lightweight when it comes to performance. It harnesses the power of the latest AMD Ryzen™ 7000 Series Processor with Radeon™ graphics, and can accommodate multiple storage combinations.
  • Latest Processor

    Powered by the latest AMD Ryzen™ 7000 Series Processor with Radeon™ graphics
  • Connectivity

    Support 6 USB ports, including 2 x Type-C ports, on-board HDMI port and Configurable port
  • Quad 4K support*

    4 display support via including Configurable port

    * When configured with Displayport or VGA

  • Multi-storage design

    Support up to 1x M.2 SSD and 1x HDD

Ultra-compact and Light

0.62L Weighted only 0.55kg


Flexible and Comprehensive Solutions

ASUS ExpertCenter PN53-S1 is no lightweight when it comes to performance. It harnesses the power of t latest AMD Ryzen™ 7000 series processor combined AMD Radeon™ graphics and plus multiple storage combinations. There’s also ultrafast PCIe® Gen3 SSD slot and DDR4 support to ensure fast boot times and rapid app loads.
  • DDR4 Memory icon

    DDR4 Memory

  • 2.5 inch HDD or 2.5 inch SSD icon

    2.5" HDD or 2.5" SSD

  • PCle 3.0x4 M.2 SSD icon

    PCle 3.0x4 M.2 SSD

  • Wi-Fi 6E 802.11zx icon

    Wi-Fi 6E 802.11zx

  • Wi-Fi 6E 802.11zx icon

    Wi-Fi 6E 802.11zx

  • 4 Displays icon

    4 Displays

  • Kensington Lock icon

    Kensington Lock

  • AI noise-canceling icon

    AI noise-canceling

4K UHD Resolution& Quadruple Display Support

PN53-S1 equips with integrated AMD Radeon™ graphics to display videos and images in stunning 4K UHD resolution*. With HDMI, Type-C Display port and a configurable port*, PN53-S1 lets you extend your workspace across up to four displays.

*Video playing or streaming in 4K or higher resolution requires dual channel memory configuration
*Configurable ports are confirmed SKU before configuring
*Actual resolution may vary depending on devices and application changes.

Hyper-realistic 8K support

PN53-S1 also supports stunning 8K UHD via USB-C or configurable DP1.4. for detail that’s 4X greater than 4K or a remarkable 16X higher than traditional Full HD output. Specifically, PN53-S1 will pump 8K visuals at 30Hz via USB-C or configurable DP.

*Video playing or streaming in 4K or higher resolution requires dual channel memory configuration
*Configurable ports are confirmed SKU before configuring
*Actual resolution may vary depending on devices and application changes.


  • MyASUS

    Your portal for system control
  • System Diagnosis

    Identify encountered problems, report sources of the issues, and provide instant suggestions.
  • Wi-Fi SmartConnect

    Automatically connect to the router with the best signal in your current environment.
  • AI Noise Cancellation

    Filters noise from microphone and incoming audio to have crystal-clear communication.
  • TaskFirst

    Personalize available internet bandwidth to particular activities.
  • Link to MyASUS

    Connect the computer with a mobile device to sharing screen, transferring files, and remotely accessing PC.
  • Fan Profile

    Provide flexibility to operate the fan at maximum speed when processing heavy tasks, and lower speed when in quiet environment.

ASUS Control Center

ASUS Control Center is a centralized IT-management suite that enhances enterprise productivity with comprehensive control through a very friendly user interface. ASUS Control Center provides high visibility and the best IT-management experiences across ASUS enterprise and commercial products.
  • Hardware & Software Monitoring icon

    Hardware & Software Monitoring

    Monitor system temperature, fan, voltage and hardware status
  • Remote Management icon

    Remote Management

    Remote desktop, power control, BIOS settings and updates
  • Asset Management icon

    Asset Management

    Software dispatch and device-metadata management
  • Mobile Control icon

    Mobile Control

    Stay in command via a smart device
  • Security icon


    Enable/disable USB storage

Enterprise Grade Security with TPM2.0

Secure Authentication

A TPM chip securely stores the authentication information (such as passwords or encryption keys) used by software to protect important data and transactions.

Secure Remote Control

For fleet management

Authority & USB Management

BIOS setting allows users to set USB enabled/disabled by port, and users can easily control and manage each USB port. Also, with authority management by setting up administrator and user password, users can easily ensure the security of the system.

ASUS Watchdog Timer

A watchdog timer (WDT) is an embedded timing device that automatically prompts corrective action upon system malfunction detection.


Automatically resetting the error system.
Good helper for remote system management.
Decreasing human resource needed.

Hyper-fast 2.5Gbps Networking

Next-generation 2.5GBase-T (2.5G) networking technology to deliver speeds of up to 2.5Gbps –2.5X faster than standard gigabit Ethernet (1G). It enables ultra-fast 2.5Gbps network access for desktop PCs, so you can easily handle the most data-intensive tasks in your office or at home.

Configurable Port

Built for All Business

Comes with DP port, VGA, COM*, or LAN for monitor or legacy devices, like barcode scanners and receipt printers. PN53-S1 can fit a wide-range of usages, including Signage, Point-Of-Sale system, KIOSK and intelligent vending machine.

*Configurable ports are confirmed SKU before configuring

  • DP icon


  • COM icon


  • VGA icon


  • LAN icon


  • Digital Display

  • Printer

  • Barcode Scanner

  • Router & Modem

Hassle Free Hardware Customization

An optional multi-storage design that accommodates M.2 SSD and 2.5-inch solid-state drives(SSD) or hard disk drives (HDD) for added storage flexibility. Users are allowed to exchange storage (HDD & M.2) and Memory easily, simply by using a screw driver.

Customize to Upgrade or Customize

All of the memory, storage drive, and wireless card can be upgraded or customized in 2 easy steps using only a screwdriver.

SSD Heatsink Design

ASUS ExpertCenter PN53-S1 also benefits from an integrated SSD heatsink that can reduce the temperature of the M.2 drive by 10°C or even cooler, compared to use without the heatsink. This helps ensure both durability and reliability, potentially saving on maintenance costs.

Exceptional Connection Experience

Wi-Fi 6

ASUS ExpertCenter PN53-S1 enables smooth streaming of high resolution videos, fewer dropped connections, and faster connections farther way from the router even in dense environment.

Wi-Fi 6E

The expanded version of Wi-Fi 6 to support extra high-speed 160MHz channels*.

*SKUs with Wi-Fi 6E only provided to certain regions or countries, depending on local regulation.
*It requires WiFi-6-compatible devices to enjoy all benefits of Wi-Fi 6 (802.11ax).
*The speed is calculated with Wi-Fi 6 devices supporting 160 MHz.
*The data refers to uplink-OFDMA.
*Actual performance may vary depending on objective environmental changes.

  • ~3X FASTER

    than standard AC 2x2 with 80 MHz channels

    improvement in dense environment for more devices

    seamless and reliable video displaying or conferencing

New Lockable VESA Mount

VESA Mount Ready for Clever Business Success

Lockable design for better security solution. Whole new lockable design avoids the device from stolen, and device can be mounted on the VESA plate with solidity.
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